A newer generation of injectable treatments has shifted the focus in aesthetic medicine away from simply adding volume, towards genuinely improving the quality and biological health of the skin. Polynucleotides, Profhilo, and biostimulators are three of the most talked-about categories in this space, and while they are sometimes lumped together as 'skin boosters', each works through a distinct mechanism.

Polynucleotides and Rejuran

Polynucleotide treatments, most recognisably represented by Rejuran, use purified DNA fragments derived from salmon to stimulate tissue repair and regeneration at a cellular level. Rather than simply hydrating the skin, polynucleotides encourage fibroblast activity, helping to rebuild the skin's own structural matrix over time. This makes Rejuran a popular choice for improving skin laxity, fine lines, and overall resilience, particularly in areas prone to thinning such as under the eyes.

Because the injection technique and depth vary depending on the area treated, Rejuran polynucleotide treatment in London should be carried out by a practitioner experienced specifically with this category of product, rather than someone trained only in traditional filler.

Profhilo and Bio-Remodelling

Profhilo occupies a different niche. Classified as a bio-remodelling injectable rather than a filler, it is made from a very high concentration of stabilised hyaluronic acid that spreads evenly beneath the skin after injection, drawing in moisture and stimulating collagen and elastin production. The result is skin that appears firmer, smoother, and more hydrated from within, rather than visibly 'filled' or contoured.

A standard course of Profhilo treatment in London typically involves two sessions around four weeks apart, using a five-point injection pattern on each side of the face.

Biostimulators: Sculptra, Ellansé, Radiesse, and Juvelook

Biostimulators form a broader category that includes products like Sculptra, Ellansé, Radiesse, and Juvelook. Rather than filling space directly, these injectables trigger the body's own collagen production, meaning results build gradually over weeks to months and tend to last considerably longer than traditional hyaluronic acid filler — often twelve to twenty-four months, depending on the product used.

Each biostimulator has a distinct profile: Sculptra is known for its very gradual, natural volumising effect across broad areas of the face; Ellansé combines an immediate lifting effect with ongoing collagen stimulation; Radiesse offers a firmer, more structural lift often used along the jaw and hands; and Juvelook, a newer Korean-developed option, is prized for improving overall skin quality alongside modest volumisation.

Choosing Between Them

The right choice among polynucleotides, Profhilo, and biostimulators depends entirely on the underlying concern — whether that is deep tissue repair, surface hydration and firmness, or long-term structural volume. A thorough, doctor-led assessment of the skin is the only reliable way to determine which regenerative pathway, or combination of pathways, will produce the best outcome.